Olive antioxidants have shown antiviral activity against many RNA viruses .e.g. viral haemorrhagic septicaemia virus, human immunodeficiency virus, influenza virus and some DNA viruses such as hepatitis B virus. Oxidative stress is implicated in the pathology of a number of viral infections. We will be investigating the effect of olive bioactive compounds as antiviral agents and we will evaluate their antioxidant role. This is an interdisciplinary research encompassing pharmacology, microbiology and biochemistry. Candidate will be trained on a variety of techniques: cell culture, virology and bioassays. In this study equine adenovirus serotype 1 will be used as a model to study the antiviral properties of olive extracts. This virus has been isolated from horses and is associated with respiratory infections in immunosuppressed horses and foals with an immature immune system.
Lower airway disease in horses is a common and performance limiting condition of horses, diagnosed by airway endoscopy and cytology. This project will evaluate aspects of this condition in our area, such as the incidence and prevalence of the condition, improved diagnosis, possible effects on performance and response to current treatments.
Meloxicam is a selective inhibitor of prostaglandin synthesis in the horse, currently registered as an anti-inflammatory and analgesic. Building on recent pharmacologic studies on this drug and using a novel methodology, this project will evaluate the efficacy of the product as a musculoskeletal analgesic in horses.