Charles Sturt University
Charles Sturt University

Dr Glenys Noble

Dr Glenys Noble

BApp(Equine Studies), PhD, GradCertUnivTeach&Learn, GradCertMgt

Glenys's PhD research centred on developing a forensic test to detect synthetic growth hormone given to racehorses. Building on her PhD research, she continues to investigate the pharmacokinetics of equine therapeutics to provide more reliable estimates of drug excretion times in competition horses. She completed 5 months' study leave at the University of Pennsylvania in 2011, developing her skills in pharmacokinetic modelling with Professor Ray Boston. She has conducted research into glucose and insulin dynamics in equids; the safety and efficacy of NSAIDs and equine oral calmative preparations and equine behaviour and welfare. Her objective measurement of reactivity in horses has been utilised by Prof Temple Grandin from Colorado State University.

Glenys has worked in the Middle East with both Australian and indigenous sheep in export and sheep dairy feedlots. She is a full accredited Livestock Export Stockperson, completing several sea voyages with sheep and cattle to Kuwait, Oman and Israel. From this work, she is conducting research into managing the physiology of livestock to cope with adverse conditions such as confinement, high temperature and humidity and alterations in diet.She is an external reviewer of efficacy and safety studies for veterinary pharmaceuticals for the Australian Pesticides and Veterinary Medicines Authority (APMVA).

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Glenys has taught a vast array of subjects including animal nutrition, equine nutrition, equine exercise physiology, pharmacology, general horse husbandry, scientific writing, and research methods.Her primary teaching roles currently are VSC332 Advanced Animal Nutrition, ASC306 Applied Animal Pharmacology and ASC412 Equine Nutrition.

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  • Pharmacokinetics of common equine medications
  • Safety and efficacy of veterinary medications
  • Insulin and glucose dynamics in horses and ponies
  • Efficacy of oral calmative preparations for horses
  • Education of culturally-diverse groups in low-stress stock handling techniques
  • Changes in rumen anatomy due to ineffective fibre content in shipboard rations
  • Improving conditions on livestock ships to enhance health and welfare for long haul journeys

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  • Member of Equestrian Australia
  • Accredited Live Export Stockperson

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JOURNAL PAPERS

  • Macomber, E., Noble, G., Brewer, K., Machin, J., Morales BriceƱo, A., O'Connell, M-A., Stirling, K., Eisenberg, R., Kudrimoti, S., Fenger, C and Tobin, T (submitted). Regulatory thresholds for xylazine: case report and review based on recent regulatory events. Canadian Veterinary Journal.
  • Viljanto, M., Scarth, J., Hincks, P., Hillyer, L., Cawley, A., Suann, C., Noble, G.K., Walker, C.J., Kicman, A.T., and Parkin, M.C. (2017). Application of testosterone to epitestosterone ratio to horse urine - a complimentary approach to detect the administrations of testosterone and its pro-drugs in Thoroughbred geldings. Drug Testing and Analysis, 9, 1328-1336.
  • Noble, G.K., Li, X., Zhang, D. and Sillence, M.N. (2016). Randomised clinical trial on the effect of a single oral administration of L-tryptophan, at three dose rates, on reaction speed, plasma concentration and haemolysis in horses, The Veterinary Journal, 213, 84-86.
  • Dodd, J., Doran, G.S., Harris, P.A. and Noble, G.K. (2015). Magnesium aspartate supplementation and reaction speed responses in horses, Journal of Equine Veterinary Science, 35, 401-402.
  • Dodd, J., Doran, G.S., Harris, P.A. and Noble, G.K. (2015). Oral magnesium supplementation alters blood and urine electrolyte concentrations in horses, Journal of Equine Veterinary Science, 35, 409-410.
  • Raidal, S.L., Kughes, K.J., Charman, A-L., Nielsen, S.G., Phillips, J.K. and Noble, G.K. (2014). Meloxicam and phenylbutazone effects on renal responses to furosemide, dobutamine and exercise in horses. American Journal of Veterinary Research, 75, 668-679.
  • Noble, G.K. and Sillence, M.N. (2013). Diurnal rhythm and effects of feeding, exercise and recombinant equine growth hormone on serum insulin concentrations in the horse. Equine Veterinary Journal, 45, 745-750. DOI: 10.1111/evj.12057.
  • Raidal, S.L., Edwards, S., Pippia, J., Boston, R.C. and Noble, G.K. (2013). Pharmacokinetics and safety of oral administration of meloxicam to foals. Journal of Veterinary Internal Medicine, 27, 300-307. DOI: 10.1111/jvim.12045.
  • Noble, G.K., Blackshaw, K.L., Cowling, A., Harris, P.A. and Sillence, M.N. (2013). An objective measure of reactive behaviour in horses. Applied Animal Behaviour Science, 144, 121-129.DOI: 10.1016/j.applanim.2012.12.009.
  • Schneiders, F.I., Noble, G.K., Boston, R.C., Dunstan, A.J., Sillence, M.N. and McKinney, A.R. (2012). Acepromazine pharmacokinetics: A forensic perspective. The Veterinary Journal, 194, 48-54. DOI: 10.1016/j.tvjl.2012.03.017
  • McGree, J.M., Noble, G.K., Schneiders, F.I., Dunstan, A.J., McKinney, A.R., Boston, R.C. and Sillence, M.N. (2012). A Bayesian approach to estimating detection times in horses: Exploring the pharmacokinetics of a urinary acepromazine metabolite. Journal of Veterinary Pharmacology and Therapeutics, DOI: 10.1111/j.1365-2885.2012.01389.x
  • Michelsen, J., Heller, J., Wills, F. and Noble G.K. (2012). The effect of surgeon experience on postoperative plasma cortisol and C-reactive protein concentrations after ovariohysterectomy in the dog: a randomised trial. Australian Veterinary Journal, 90, 12, 474a-478. DOI: 10.1111/j.1751-0813.2012.01013.x
  • Noble, G.K., Edwards, S., Pippia, J., Boston, R.C. and Raidal, S.L. (2012). Pharmacokinetics and safety of single and multiple oral doses of meloxicam in adult horses. Journal of Veterinary Internal Medicine, 26: 1192-1201. DOI: 10.1111/j.1939-1676.2012.00976.x
  • D'Arcy-Moskwa, E., Noble, G.K., Weston, L., Boston, R.C. and Raidal, S.L. (2012). Effects of meloxicam and phenylbutazone on equine gastric mucosal permeability. Journal of Veterinary Internal Medicine, 26, 1494-1499. DOI: 10.1111/j.1939-1676.2012.01004.x
  • D'Arcy-Moskwa, E., Weston, L., Noble, G.K., and Raidal, S.L. (2011). Determination of sucrose in equine serum using liquid chromatography-mass spectrometry (LC/MS). Short Communication, Journal of Chromatography B., 879, 30, 3668-3671. DOI:10.1016/j.jchromb.2011.09.049
  • Tinworth, K.D., Wynn, P.C., Boston, R.C., Harris, P.A., Sillence, M.N., Thevis, M., Thomas, A. and Noble G.K. (2011). Evaluation of commercially available insulin assays being used to measure equine insulin. Domestic Animal Endocrinology, 41, 2, 81-90. DOI: 10.1016/j.domaniend.2011.05.001
  • Tinworth, K.D., Boston, R.C., Harris, P.A., Sillence, M.N., Raidal, S.L. and Noble, G.K. (2011). The effect of oral metformin on insulin sensitivity in insulin-resistant ponies. The Veterinary Journal, 191, 79-84. DOI:10.1016/j.tvjl.2011.01.015
  • Tinworth, T.D., Edwards, S., Harris, P.A., Sillence, M.N., Hackett, L.P. and Noble G.K. (2010). Pharmacokinetics of an enteral dose of metformin in insulin-resistant ponies. American Journal of Veterinary Research, 71, 1201-1206. DOI: 10.2460/ajvr.71.10.1201
  • Tinworth, T.D., Harris P.A., Sillence M.N. and Noble G.K. (2010). Potential treatments for insulin resistance in the horse: A comparative multi-species review. The Veterinary Journal, 186, 282-291. doi: 10.1016/j.tvjl.2009.08.032.
  • Giles, C., Cavanagh, H. M. A., Noble, G.K. and Vanniasinkam, T. (2010). Prevalence of equine adenovirus antibodies in horses in New South Wales, Australia. Short Communication, Veterinary Microbiology, 143, 401-404. DOI:10.1016/j.vetmic.2009.11.042
  • Tinworth, K.D., Wynn, P.C., Harris, P.A., Sillence, M.N., and Noble, G.K. (2009). Optimising the Siemens Coat-A-Count radioimmunoassay to measure insulin in equine plasma. Journal of Equine Veterinary Science, 29, 411-413.
  • Noble, G.K., Brockwell, Y.M., Munn, K.J., Harris, P.A., Davidson, H.P.B., Li, X., Zhang, D., Sillence, M.N. (2008). Effects of a commercial dose of l-tryptophan on plasma tryptophan concentrations and behaviour in horses. Equine Veterinary Journal, 40,1, 51-56. DOI: 10.2746/042516407X238503
  • Noble, G.K., Houghton, E., Roberts, J., Faustino-Kemp, J., de Kock, S.S., Swanepoel, B.C., Sillence, M.N. (2007).  Effect of exercise, training, diurnal rhythm, age and gender on insulin-like growth factor-1 in the horse. Journal of Animal Science, 85, 163-171. DOI:10.2527/jas.2006-210

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Book Chapters

  • Lundgren, J.D., Boston, R.C. and Noble, G.K. (2012). Circadian Rhythms Associated with NES. In Night Eating Syndrome: Definition, Assessment and Treatment, Eds Lundgren, J.D., Allison, K.C. and Stunkard, A.J. Guildford Publications, Inc, New York. 40-57.

Editorials

  • Sillence M.N., Noble G.K. and McGowan C. (2005). Fast food and fat fillies: The ills of western civilisation. The Veterinary Journal, 172, 3, 396-7.

Refereed Conference Papers

  • Noble, G.K., Sillence, M.N., Boston, R.C., Schneiders, F.I., Zahra, P., Fraser, L.H,., Murthi, A., Vine, J.H., Cawdell-Smith A.J., Bryden W.L., , Dunstan, L., Booth, J., Salamakha, I., Chua, A.N., Keledjian, J. and Cawley, A.T. (2014).  ETRA update: Excretion rates of single and repeated doses of procaine penicillin plus butorphanol, xylazine and a butorphanol-xylazine combination dose in the horse. Proceedings of the 20th International Conference of Racing Analysts and Veterinarians, Mauritius. 83-90.
  • Scarth, J., Cawley, A., Viljanto, M., Bright, J., Hincks, P., Pearce, C., Teale, P., Hillyer, L., Hall, J., Suann, C. and Noble G. (2014). The urinary steroid profile of geldings with 'elevated' endogenous production compared to those administered anabolic agents. Proceedings of the 20th International Conference of Racing Analysts and Veterinarians, Mauritius. 277-284.
  • Dodd, J. A., Knight, P.K. and Noble, G.K. (2014). Determining forces generated using a padded whip and impacts on the horse. Proceedings of the 20th International Conference of Racing Analysts and Veterinarians, Mauritius. 450-454.
  • Knight P.K. and Noble G.K. (2012). Effect of diet on plasma total carbon dioxide. The 19th International Conference of Racing Analysts and Veterinarians, Philadelphia, Pennsylvania, USA.
  • Glowacki, L.L., Dowarkasing, R., Moon-Borton, A., Schneiders, F.I., Noble, G.K., Sillence, M.N. and Vine J.H. (2010). The metabolism and excretion of prilocaine in the horse after subcutaneous administration. The 18th International Conference of Racing Analysts and Veterinarians. Queenstown, New Zealand.
  • Vine, J.H., Glowacki, L.L. Schneiders, F.I. and Noble G.K. (2008) Pharmacokinetics of Equine Medications – Hydrocortisone: Method validation and preliminary results. The 17th International Conference of Racing Analysts and Veterinarians. Antalya, Turkey.
  • Noble, G. K. and Sillence, M. N. (2000). The potential of mediator hormones as markers of growth hormone abuse in racehorses. Proceedings of the 13th International Conference of Racing Analysts and Veterinarians, Cambridge, UK. R and W Publications., Newmarket, UK. 88–90.
  • Noble, G. K. and Sillence. M. N. (2000). Technical considerations when measuring IGF-1 and IGF binding proteins in the horse. Proceedings of the 13th International Conference of Racing Analysts and Veterinarians, Cambridge, UK. R and W Publications., Newmarket, UK. 314–320
  • DeKock, S.S., Rodgers, J.P., Swanepoel, B.C., Price, J.S., Noble, G.K. and Sillence, M.N. (2000) Potential markers of bone formation and growth hormone treatment in the horse. Proceedings of the 13th International Conference of Racing Analysts and Veterinarians, Cambridge, UK. R and W Publications., Newmarket, UK.
  • DeKock, S.S., Rodgers, J.P., Houghton, E., Noble, G.K. and Sillence M.N. (2000) Growth hormone abuse: an investigation of IGF-1 levels in the horse. Proceedings of the 13th International Conference of Racing Analysts and Veterinarians, Cambridge, UK. R and W Publications., Newmarket, UK.

Technical Bulletin

  • Noble, G.K., Dodd, J.A., Neilsen, S. Spurrell, B.E. and Knight, P.K. (2014). Determining forces generated using a padded whip and impacts on the horse. RIRDC Publication No. 14/075.
  • Sillence, M.N., Noble, G.K., Schneiders, F.I., Bryden, W., Cawdell-Smith, A.J., de Laat, M., Jarrett, M., Young, B., McKinney, A., Cawley, A., Booth, J., Vine, J., Glowacki, L., McGree, J., Boston, R., Nelis, S., Kirkpatrick, C., Shaw, N. and Smyth B. (2012). The pharmacokinetics of equine medications. RIRDC Publication No. 11/117.
  • Vine, J.H., Selvadurai, N.S., Glowacki, L.L., Krstevska, D., Zahra, P.W., O'Callaghan, P., Nelis, S., Sievers, K., Bailey, A., Davies, B., Young, B., Bryden, W., Cawdell-Smith, J., Shaw, N., Kirkpatrick, C., Lissen, L., Basgallop, N., Noble, G.K., Turco, B., Sillence, M.N., McKinney, A.R. and Stenhous, A.M. (2007). Detecting three common drugs in horses: frusemide, betamethasone and triamcinolone acetonide. RIRDC Publication No. 07/129.
  • Sillence, M.N., Noble G.K., DeKock, S.S., Rodgers, J.P., Swanepoel, B.C., Houghton, E., Faustino-Kemp, J. and Jackson, L.S. (2000).  Measuring insulin-like growth factor-1 (IGF-1) in horses.  DSL Technical Release.

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  • Ferris, C.A., Heller, J., Lammers, G., Brookes, V. and Noble G.K. (2015). Stress and E.coli shedding in cattle. The 14th Conference of the International Society for Veterinary Epidemiology and Economics (ISVEE 2015), Yucatan, Mexico.
  • Noble, G.K., Brewer, K., O'Connell, M., Stirling, K.H., Briceno, A.M., Machin, J., Hughes, C and Tobin, T (2015). Revisiting RMTC xylazine guidelines with Australian assistance. National Horsemens' Benevolent and Protective Association Summer Convention, Denver, Colorado, August 8th 2015.
  • Dodd, J.A., Noble, G.K. and Knight, P.K. Estimation of forces generated by a jockey using the padded whip in a routine jump out. Proceedings of the 2015 Equine Science Society Symposium. St Pete's Beach, Florida, USA.
  • Dodd, J.A., Doran, G., Harris, P.A. and Noble G.K. (2015) Magnesium aspartate supplementation and reaction speed response in horses. Proceedings of the 2015 Equine Science Society Symposium. St Pete's Beach, Florida, USA.
  • Dodd, J.A., Doran, G., Harris, P.A. and Noble G.K. (2015) Oral Magnesium supplementation alters blood and urine electrolyte concentrations in horses. Proceedings of the 2015 Equine Science Society Symposium. St Pete's Beach, Florida, USA.
  • Noble, G.K., Dodd, J.A., Neilsen, S. and Knight P.K. (2014). Determining forces generated using a padded whip and impacts on the horse. The 20th International Conference of Racing Analysts and Veterinarians, Mauritius.
  • Noble, G.K., Sillence, M.N., Boston, R.C., Schneiders, F.I., Zahra, P., Fraser, L.H., Murthi, A. and Vine, J.H. (2014). ETRA update: Excretion rates of single and repeated doses of procaine penicillin in the horse. The 20th International Conference of Racing Analysts and Veterinarians, Mauritius.
  • Scarth, J., Cawley, A., Viltanto, M., Bright, J., Hincks, P., Pearce, C., Teale, P., Hillyer, L., Hall, J., Suann, C. and Noble, G. (2014) The urinary steroid profile of geldings with 'elevated' endogenous production compared to those administered anabolic agents. The 20th International Conference of Racing Analysts and Veterinarians, Mauritius.
  • Noble, G.K., Knight, P.K. and Dodd, J.A. (2014). Putting forces generated by a padded whip into context. Australasian Equine Science Symposium. 5, 54.
  • Dodd, J.A., Knight, P.K. and Noble, G.K. (2014). Investigating relationships between deceleration and force parameters for a padded whip during routine jumpouts. Australasian Equine Science Symposium. 5, 55.
  • Lennox, E., Noble, G.K., Nielsen, S.G. and Raidal, S.L. (2013). Comparison of meloxicam and phenylbutazone on lipopolysaccharide induced synovitis in horses. 2013 American College of Veterinary Internal Medicine Forum, Seattle, Washington.
  • Skinner, B.A., Kratochwil, N.R., Russell, K.G., and Noble, G.K. (2013). Effect of meal frequency on plasma glucose in thoroughbred mares. Proceedings of the 2013 Equine Science Symposium, Ruidoso, New Mexico.
  • Morris, T., Hillyer, L., Noble, G., Paine, S., Pearce, C., Sams, R., and Toutain, P-L. (2012) Overview of administration studies on corticosteroids. The 19th International Conference of Racing Analysts and Veterinarians, Philadelphia, USA.
  • Raidal, S-L., Hughes, K. J., Charman, A-L., Neilsen, S., and Noble G.K. (2012). Effects of meloxicam and phenylbutazone on renal responses to furosemide, dobutamine and exercise in healthy horses. Journal of Veterinary Internal Medicine, 26, 748.
  • Tinworth, T.D., Raidal, S.L., Boston, R.C., Harris, P.A., Sillence, M.N. and Noble G.K. (2011). Effect of diet on insulin sensitivity in insulin-resistant ponies. Proceedings of the 2011 Equine Science Society Symposium. 258-259.
  • Tinworth, T.D., Raidal, S.L., Harris, P.A., Sillence, M.N. and Noble G.K. (2011). Comparing glycaemic and insulinaemic responses of ponies and horses to dietary glucose. Proceedings of the 2011 Equine Science Society Symposium. 301.
  • Noble, G.K., Cawdell-Smith A.J., Bryden, W.L. and Sillence, M.N. (2011). Observations of insulin responses to five glucocorticoids commonly used in equine medicine. Proceedings of the 2011 Equine Science Society Symposium. 303-304.
  • Tinworth, T.D., Boston, R.C. Harris, P.A., Sillence, M.N., Raidal, S.L. and Noble G.K. (2010). Efficacy of oral metformin in insulin-resistant ponies. Australasian Equine Science Symposium. 3, 35.
  • Noble, G.K., McKinney, A. R., Schneiders, F.I., Dunstan, A.J., Sillence, M.N. and Boston, R.C. (2010). Preliminary pharmacokinetics of acepromazine and its metabolite hydroxyethylepromazine sulfoxide. Australasian Equine Science Symposium. 3, 52.
  • Noble, G.K., Vine, J.H., Sillence, M.N. and Boston, R.C. (2010). The metabolism of Solu-Cortef®: subsequent distribution of hydrocortisone hemisuccinate and hydrocortisone. Australasian Equine Science Symposium. 3, 54.
  • Tinworth, T.D., Glowacki, L., Boston, R.C. Harris, P.A., Sillence, M.N.and Noble G.K. (2010). Evaluation of commercially-available cortisol assays being used to measure equine cortisol. Australasian Equine Science Symposium. 3, 56.
  • Noble, G.K. and Sillence, M.N. (2010). Recombinant equine growth hormone (eGH): A therapy for obesity? Australasian Equine Science Symposium. 3, 58.
  • Raidal, S.L., Pippia, J and Noble G.K. (2009).  Pharmacokinetics and safety of oral doses of meloxicam in foals less than 6 weeks of age. American Association of Equine Practitioners 55th Annual Convention, Las Vegas, Nevada. December 5-9.
  • Tinworth, K.D., Wynn, P.C., Harris, P.A., Sillence, M.N. and Noble, G.K. (2009). Use of the Siemens Coat-A-Count insulin radioimmunoassay to measure insulin in equine plasma. Proceedings, Equine Science Society Meeting, Keystone, Colorado. May 29-31.
  • Raidal, S.L., Pippia, J and Noble G.K. (2009) Safety evaluation of repeated doses of meloxicam and phenylbutazone in adult horses. 31th Bain Fallon Memorial Lectures, Equine Veterinarians Australia, Sunshine Coast, July 20-24.
  • Tinworth, T.D., Edwards, S., Harris, P.A., Sillence, M.N., Hackett, L.P. and Noble G.K. (2009) Pharmacokinetics of an oral dose of metformin in insulin-resistant ponies. Australian College of Veterinary Scientists College Science Week, Gold Coast, 2-4 July.
  • Raidal, S.L., Pippia, J. and Noble, G.K. (2008). Pharmacokinetics of meloxicam in foals less than 6 weeks of age. 30th Bain Fallon Memorial Lectures, Equine Veterinarians Australia, Cairns, July 13-18.
  • Sillence, M.N., Bryden, W.L., Cawdell-Smith, A.J., Jarrett, M.W., Kirkpatrick, C.M., McKinney, A.R., Noble G.K., Russo, C., Schneiders F.I., Vine J.H. and Young E.B. (2008).   Determining the pharmacokinetics of equine medications. 30th Bain Fallon Memorial Lectures, Equine Veterinarians Australia, Cairns, July 13-18.
  • Tinworth K. D., Harris, P. A., Sillence, M. N. and Noble G. K. (2008). Insulin resistance in equids, its association with laminitis, treatment and prevention. Australian College of Veterinary Scientists College Science Week, Gold Coast, 3-5 July.
  • Bryden W.L., Cawdell-Smith A.J., Jarrett M.W., Kirkpatrick, C.M., McKinney, A.R., Noble, G.K., Russo, C., Schneiders, F.I., Sillence, M.N., Vine, J.H. and Young, E.B. (2008). Equine therapeutics research Australia:  a consortium determining reliable excretion times for equine medications. Proceedings of the Australian Equine Science Symposium, 2, 14.
  • Noble G.K., Pippia, J. and Sillence, M.N. (2008). Safety and efficacy of a single dose of l-tryptophan as a calmative for horses. Proceedings of the Australian Equine Science Symposium, 2, 33.
  • Blackshaw, K., Harris, P.A. Sillence, M.N. and Noble G.K. (2008). Using flight speed as an objective measurement of reactive behaviour in horses.  Proceedings of the Australian Equine Science Symposium, 2, 55.
  • Noble, G.K., Y.M. Brockwell, K.J. Munn, P.A. Harris, H.P.B. Davidson, X. Li, D. Zhang, M. Cao, W.L. Bryden and  M.N. Sillence (2006).  Effect of oral tryptophan on the reaction of horses to a novel person or object. Proceedings of the Australian Equine Science Symposium, 1, 17.
  • Noble G.K., K.J. Munn, Y.M. Brockwell, H.E. Austin, P.A. Harris, H.P.B. Davidson, D. Zhang, X. Li, M. Cao, W.L. Bryden, and M.N. Sillence (2005). Do commercial tryptophan pastes elevate plasma tryptophan concentrations in horses? Nutrition Society of Australia, 29th Annual Meeting, Melbourne, Vic.
  • Noble G.K., Houghton, E., Price J.S., DeKock, S.S., Swanepoel, B.C., Rodgers, J.P. and Sillence M.N. (2001). Detecting the growth hormone-treated horse using mediator hormones. RIRDC International Horse Industry Symposium, Sydney, N.S.W.
  • Noble, G.K., Price, J and Sillence, M.N. (2000). Detecting the growth hormone-treated horse.  The 19th Joint Meeting of the British Endocrine Society Meeting, Birmingham U.K.
  • Price, J.S., Jackson, B., Noble, G.K., Horner, C., Houghton, E. And Sillence M.N. (2000). Growth hormone administration increases bone turnover in horses. The 19th Joint Meeting of the British Endocrine Society Meeting, Birmingham U.K.

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