Sox proteins belong to a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. There are 20 SOX protein present in human showing at least 50% amino acid similarity with the HMG box in SRY. The developmentally important Sox family has no singular function, and many members possess the ability to regulate several different aspects of development. To regulate mentioned activities, binding to DNA is one of their most important features. In the Forwood’s Lab, I am working on structural basis of Sox: Nucleic acid interaction. We are using X-ray crystallography, NMR, and Cryo-EM to gain Sox:Nucleic acid structure.
Supervisors - Professor Jade Forwood, Professor Shane Raidal, Dr Daniel Luque