Middle East respiratory syndrome-related coronavirus (MERS-CoV) is an emerging zoonotic coronavirus that causes severe pneumonia and acute respiratory distress syndrome in humans, with a case fatality rate of 36%. In my project, I am investigating the accessory proteins MERS-CoV in complex with host receptors. These interactions are important for suppression of innate immunity. The approach will be to clone specific genes of the virus and host proteins, express these proteins recombinantly in bacteria, purify the complex using a combination of chromatography methods, and to determine the structures at high resolution using the Australian synchrotron. The aims of this PhD project are to express and purify MERS-CoV accessory proteins in complex this with human proteins to determine the binding interface and potential novel sites for development of therapeutics.