Charles Sturt University
Charles Sturt University

Dr Brendan Adams

Dr Brendan Adams

BSc (Hons), BCom (Melbourne)
PhD (Melbourne)

Dr Adams completed his PhD at The University if Melbourne in 2008 researching epileptiform activity in in vitro models of temporal and absence epilepsies under the supervision of Profs David Williams and Terence O'Brien and Drs Chris Reid and Damian Myers. Subsequently he undertook a postdoctoral year with Prof. Gordon Lynch establishing an in vivo Ca2+ imaging technique for skeletal muscle.

In 2010 Dr Adams researched ketamine-induced network activity in schizophrenia in the laboratory of A.Prof. Didier Pinault at the University of Strasbourg (INSERM Unit U666), France.

He joined CSU as a lecturer in Anatomy and Physiology in July 2009.

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Teaching

Current subjects taught
  • Subject convenor BMS291 Pathophysiology and Pharmacology 1 across 5 campuses and distance education and subject coordinator BMS291 and BMS292, Wagga Wagga Campus.
  • BMS191 and BMS192 Human Biosciences 1 and 2 - foundation anatomy and physiology subjects for allied health course
  • BMS129 Physiological Sciences 1 – foundation anatomy and physiology subjects for medical science and pharmacy courses
  • BMS233 Nutritional Physiology special topic: Immune function and nutrition
  • BMS310 Disease Processes – 3rd year Pathophysiology subject for medical science and pharmacy courses
  • Doctoral Supervision – Santhi Chigurupati, Doctor of Health Science, current
  • Honours co-supervision – Mr Andrew Dombrovski, Honours 1st Class 2012

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Research

  • Dr Adam's primary research interests lie in the neurophysiological modulators of consciousness and disorders of consciousness, cognition, awareness and arousal.  Two particular disorders have been focal points for my research to date, namely epilepsies and schizophrenia. These disorders both involve impairment to healthy conscious physiology: transient loss of consciousness in the case of epileptic seizures; and varying degrees of aberrant conscious processing in the case of schizophrenia. He has ongoing collaborations with the University of Strasbourg and the University of Melbourne investigating the neurophysiological alterations underlying these disorders.
  • Neuronal plasticity is his second area of interest, particularly the plastic potential of central nervous system neurons to regenerate after traumatic injury given the appropriate conditions. In collaboration with St. Vincent’s Institute of Medical Research and the University of Wollongong he is investigating nanoscaffolding technologies as a potential matrix for applied facilitation of neuronal plasticity, particularly relating to spinal cord injury. This project also includes components of muscle and cartilage regeneration with the aim to develop future therapies for motor unit, muscle and joint regeneration related to trauma, muscular dystrophy, motor neuron disease and associated disorders. This collaboration is his primary research activity this year and is anticipated to develop new grant applications in 2014 together with Research Higher Degree student supervision and several papers in high impact journals.
  • Finally, the contribution of neurobiology to various psycho-social conditions is a research interest, and this is being explored through an interdisciplinary group at CSU including a geneticist, psychologist, social worker and philosopher to develop a greater understanding of the interface of biology and sociology. Coupled with this is an investigation of how mind and neurophysiology are related, and how meditation and hypnosis may modulate neuronal function. The role of exercise on neural function and mental health is also a consideration.

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Publications

  • Kulikova SP, Tolmacheva EA, Anderson P, Gaudias J, Adams BE, Zheng T, Pinault D, 2012, Opposite effects of ketamine and deep brain stimulation on rat thalamocortical information processing, European Journal of Neuroscience, doi: 10.1111/j.1460-9568.2012.08263.x. [Epub ahead of print]
  • Adams BE, Kyi M, Reid CA, Myers DE, Xu S, Williams DA, O'Brien TJ., 2011, Seizure-like thalamocortical rhythms initiate in the deep layers of the cortex in a co-culture model, Experimental Neurology; 227(1):203-9.
  • Adams BE, Reid CA, Myers D, Ng C, Powell K, Phillips AM, Zheng T, O'Brien TJ, Williams DA., 2009, Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1, Experimental Neurology; 219(1):249-57.
  • Adams BE, Reid CA, Myers D, O'Brien TJ, Williams DA., 2008, Sub region-specific modulation of synchronous neuronal burst firing after a kainic acid insult in organotypic hippocampal cultures, BMC Neuroscience; 9:59.
  • Hodge JM, Kirkland MA, Aitken CJ, Waugh CM, Myers DE, Lopez CM, Adams BE, Nicholson GC., 2004, Osteoclastic potential of human CFU-GM: biphasic effect of GM-CSF, Journal of Bone Mineral Research, 19(2):190-9.
Presentation at Scientific Conferences:
  • 2011  Society for Neuroscience Conference, Washington DC, USA
  • 2010  Neurex Neuroscience Conference, Basel, Switzerland.
  • 2008  Australian Physiology Society Conference, Melbourne, Australia
  • 2007  American Epilepsy Society Conference, Philadelphia PE, USA
  • 2006 Federation of European Neuroscience Societies Conference, Vienna, Austria
  • Australian Neuroscience Society Conference, Sydney, Australia
  • 2004  Australian Fluorescence Imaging Workshop, Sydney, Australia

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