Charles Sturt University
Charles Sturt University

Dr Linda Hazell

Dr Linda Hazell

BSc (Hons class 1 div 1), PhD, Grad Cert Adult Ed, Cert IV in Training and Assessment, Grad Cert in Math

Dr Hazell teaches biomedical science to a range of students in health related subjects. She encourages her students to enjoy the subject and analytically and critically reflect on the information available.

Dr Hazell graduated from the University of NSW with a Bachelor of Science and first class Honours in Biochemistry.  She then worked at the Heart Research Institute (HRI) in Camperdown, Sydney, completing a PhD (University of Sydney) and post-doctoral work there.  Dr Hazell discovered that hypochlorite causes damage to proteins and low density lipoprotein, which may be relevant to the pathogenesis of atherosclerosis.

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Dr Hazell has taught biomedical science since 2008 to a range students enrolled in health related subjects at Charles Sturt University or the University of Newcastle. Her teaching qualifications include a Graduate Certificate in Adult Education through the University of Technology, Sydney.  She also has a Certificate IV in Assessment and Training.

Dr Hazell enjoys making difficult scientific concepts accessible to students from a range of backgrounds.  She develops computer-assisted learning tasks and physical activities to assist in this process.

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Dr Hazell’s main research focus has been tissue damage by oxidants of the immune system and she has published in a number of peer reviewed journals. Her PhD thesis is entitled ‘Hypochlorite-oxidised low-density lipoproteins in human atherosclerosis’.  Damage to arterial walls has been shown to contribute to atherosclerosis (thence causing heart attack and stroke), although the pivotal factors remain controversial. Hypochlorite/hypochlorous acid is a strong oxidant produced by white blood cells of the immune system.  Dr Hazell discovered that hypochlorite causes damage relevant to atherosclerosis including oxidation of low density lipoproteins (LDL).  This damage can be found in human atherosclerotic lesions associated with foam cells that are a crucial component of the disease pathology.

Dr Hazell also has research interests in patient health literacy, motivation and self-efficacy, the effect these factors can have on patient outcomes and interventions that can be used to improve these factors.

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Dr Hazell is currently a member of the Australian Society for Medical Research.

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Book Chapter

Yuan, X.M., Brunk, U., Hazell, L.J. (2000) The morphology and natural history of atherosclerosis in "Atherosclerosis:Gene expression, cell interactions and oxidation" Eds. Dean, R.T. and Kelly, D.T. Oxford University Press: Oxford, UK.

Peer Reviewed Journal Articles

Hazell, L.J. and Stocker, R. (1993) Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages. Biochem. J. 290, 165-172.

Hazell, L.J., van den Berg, J.J.M. and Stocker, R. (1994) Oxidation of low-density lipoprotein causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation. Biochem. J. 302, 297-304.

Malle, E., Hazell, L., Stocker, R., Sattler, W., Esterbauer, H. and Wäg, G. (1995) Immunologic detection and measurement of hypochlorite-modified low density lipoprotein with specific monoclonal antibodies. Arterioscler. Thromb. Vasc. Biol. 15, 982-989.

Hazell, L.J., Flowers, D., Waeg, G., Malle, E., Arnold, L. and Stocker, R. (1996) Presence of hypochlorite-modified protein in human atherosclerotic lesions. J. Clin. Invest. 97, 1535 - 1544.

Hazell, L.J. and Stocker R. (1997) a-Tocopherol does not inhibit hypochlorite-induced oxidation of apolipoprotein B-100 of low density lipoprotein. FEBS Letts. 414, 541-544.

Hazell, L.J., Davies, M.J. and Stocker, R. (1999) Secondary radicals derived from chloramines of apolipoprotein B-100 contribute to HOCl-induced LDL lipid peroxidation. Biochem. J. 339, 489-495.

Yuan, X.M., Brunk, U., Hazell, L.J. (2000) The morphology and natural history of atherosclerosis in "Atherosclerosis:Gene expression, cell interactions and oxidation" Eds. Dean, R.T. and Kelly, D.T. Oxford University Press: Oxford, UK.

Hazell, L. Baernthaler, G., Stocker, R. (2001) Correlation between intima-to-media ratio, apolipoprotein B-100, myeloperoxidase, and hypochlorite-oxidized proteins in human atherosclerosis. Free Radicals Biol. Med. 31, 1254-1262.

Hazell, L. J., Fu, H., Dean, R. T., Stocker, R. & Truscott, R. J. (2002). Is hypochlorous acid (HOCl) involved in age-related nuclear cataract? Clinical and Experimental Optometry, 85(2), 97–100.

Martinic G; Hazell L; Stocker R. (2003) Vascular microdissection, perfusion, and excision of the murine arterial tree for use in atherogenic disease investigations. Contemp. Topics Lab. Animal Sci. 42, 47-52.

Abstracts

Legge, L and Stocker, R. (1991) Hypochlorite-mediated oxidative modification of human low density lipoprotein. 30th Ann. Meeting Australian Society for Medical Research (Canberra, Australia), Presentation.

Hazell, L. and Stocker, R. (1993) Hypochlorite-mediated oxidative modification of human low-density lipoprotein. Meeting of the Australasian Society for free radical research (Christchurch NZ, Oct 1-3), Presentation.

Hazell, L.J., Wäg, G., Malle, E., van den Berg, J.J.M. and Stocker, R. (1994) Hypochlorite-mediated oxidative modification of human low-density lipoprotein causes changes which have similarities to LDL isolated from human atherosclerotic lesions. Meeting of the NSW branch of the Australian Society for Medical Research. (Sydney, 22nd June 1994), Presentation.

Hazell, L.J., Wäg, G., Malle, E., van den Berg, J.J.M. and Stocker, R. (1994) Hypochlorite-oxidised LDL: Similarities to LDL from atherosclerotic lesions. International Society for Free Radical Research. (Sydney, 6-10 Nov. 1994), Presentation.

Hazell, L.J., Wäg, G., Malle, E., van den Berg, J.J.M., Arnold, L. and Stocker, R. (1995) Hypochlorite-oxidised LDL: Its relevance to atherosclerosis. Australian Atherosclerosis Society. 21st Annual Scientific Meeting. (Canberra, Aug 8-11), Presentation.

Hazell, L.J., Wäg, G., Malle, E., Arnold, L. and Stocker, R. (1995) Distribution and characterization of antigen(s) recognized by a HOCl-oxidised protein specific antibody in human arteries. Meeting of the Australasian Society for free radical research (Wollongong, Nov 5-7), Presentation.

Hazell, L.J., Davies, M. and Stocker, R. (1997) Direct and indirect oxidation of LDL using reagent hypochlorite and the effect of vitamin E on such reactions. Meeting of the Australian Atherosclerosis Society (Leura, Sep 12-15), Poster.

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