Charles Sturt University
Charles Sturt University

Dr Louise Pemberton

Dr Louise Pemberton

BSc (Hons). PhD

Louise graduated from Trinity College Dublin with a BSc (Hons) in Microbiology. On arrival in Australia she commenced work at St. Vincent's Hospital in Sydney and worked for many years in the HIV neurological research group under the guidance of Professor Bruce Brew. Their particular interest was in the pathogenesis of HIV associated dementia. Louise's PhD at St. Vincent's Hospital investigated the molecular mechanisms involved in the pathogenesis of HIV associated dementia. This research has been recognised  on an international level and much of the work has been presented  at international HIV conferences. Louise moved to Albury in 2011 with a keen interest in teaching and has been employed by Charles Sturt University since.

Positions and Roles
  • Lecturer for the Biomedical Sciences program

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Teaching

Louise has been teaching for the Biomedical Sciences program at CSU since 2011. Prior to this she worked at St. Vincent's Hospital in Sydney. This position involved the education of many students and employees in virological and immunological methods. Of particular importance was safe laboratory practice in a high containment HIV laboratory.

Subjects Delivered

  • BMS161: Cell Immunity Musculoskeletal
  • BMS162: Cardiopulmonary & Renal
  • BMS191: Human Bioscience 1
  • BMS192: Human Bioscience 2
  • BMS236: Pathophysiology
  • BMS291: Patho & Pharm 1
  • BMS292: Patho & Pharm 2

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Research and Publications

Louise's main research interests have been neurological complications of viral infection. In particular, the effect of different HIV strains on the production of the neurotoxin,  Quinolinic acid. Other research interests have included the investigation of clinical markers for the diagnosis of HIV associated dementia.  Since commencing employment at CSU  Louise has been involved with studies investigating the chronic complications associated with Diabetes.

List of Publications
  • Pemberton LA, Stone E, Price P, van Bockxmeer F, Brew BJ. The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia. HIV Med. 2008 Oct;9(8):677-80. Epub 2008 Jul 8
  • Brew BJ, Pemberton L, Blennow K, Wallin A, Hagberg L. CSF amyloid beta42 and tau levels correlate with AIDS dementia complex. Neurology. 2005 Nov 8;65(9):1490-2.
  • Brew BJ, Pemberton L, Ray J. Can the peripheral blood monocyte count be used as a marker of CSF resistance to antiretroviral drugs? J Neurovirol. 2004;10 Suppl 1:38-43.
  • Guillemin GJ, Kerr SJ, Pemberton LA, Smith DG, Smythe GA, Armati PJ, Brew BJ. IFN-beta1b induces kynurenine pathway metabolism in human macrophages: potential implications for multiple sclerosis treatment. J Interferon Cytokine Res. 2001 Dec;21(12):1097-101.
  • Pemberton LA, Brew BJ. Cerebrospinal fluid S-100beta and its relationship with AIDS dementia complex. J Clin Virol. 2001 Oct;22(3):249-53.
  • Smith DG, Guillemin GJ, Pemberton L, Kerr S, Nath A, Smythe GA, Brew BJ. Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat. J Neurovirol. 2001 Feb;7(1):56-60.
  • McPhee DA, Greenway AL, Holloway G, Smith K, Deacon N, Pemberton L, Brew BJ. Anomalies in Nef expression within the central nervous system of HIV-1 positive individuals/AIDS patients with or without AIDS dementia complex. J Neurovirol. 1998 Jun;4(3):291-300.
  • Kerr SJ, Armati PJ, Pemberton LA, Smythe G, Tattam B, Brew BJ. Kynurenine pathway inhibition reduces neurotoxicity of HIV-1-infected macrophages. Neurology. 1997 Dec;49(6):1671-81.
  • Pemberton LA, Kerr SJ, Smythe G, Brew BJ. Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha. J Interferon Cytokine Res. 1997 Oct;17(10):589-95.
  • Cunningham AL, Naif H, Saksena N, Lynch G, Chang J, Li S, Jozwiak R, Alali M, Wang B, Fear W, Sloane A, Pemberton L, Brew B. HIV infection of macrophages and pathogenesis of AIDS dementia complex: interaction of the host cell and viral genotype. J Leukoc Biol. 1997 Jul;62(1):117-25.
  • Brew BJ, Pemberton L, Cunningham P, Law MG. Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stage. J Infect Dis. 1997 Apr;175(4):963-6.
  • Brew BJ, Dunbar N, Pemberton L, Kaldor J. Predictive markers of AIDS dementia complex: CD4 cell count and cerebrospinal fluid concentrations of beta 2-microglobulin and neopterin. J Infect Dis. 1996 Aug;174(2):294-8.
  • Brew BJ, Evans L, Byrne C, Pemberton L, Hurren L. The relationship between AIDS dementia complex and the presence of macrophage tropic and non-syncytium inducing isolates of human immunodeficiency virus type 1 in the cerebrospinal fluid. J Neurovirol. 1996 Jun;2(3):152-7.
  • Dunbar N, Pemberton L, Perdices M, Brew BJ. Clinical Markers of the Presence of Dementia and Neuropsychological Impairment in HIV Infection J NeuroAIDS. 1996;1(4):31-48.
  • Brew BJ, Corbeil J, Pemberton L, Evans L, Saito K, Penny R, Cooper DA, Heyes MP. Quinolinic acid production is related to macrophage tropic isolates of HIV-1.J Neurovirol. 1995 Dec;1(5-6):328-9.

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